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Hyperbaric Oxygen Treatment for Post-Traumatic Stress Syndromes
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Dr. Shai Efrati takes us through the core of the biology of the brain and how hypoxemia works in the body. He then discusses what is needed for regeneration and how the hyperoxic-hypoxic paradox works and some studies supporting the paradox. He then hands it off to Dr. Keren Doenyas-Barak who walks us through the pathogenesis of PTSD, first starting with the biological point of view, and then she dives into the study of HBOT and PTSD. Dr. Ilan Kutz finishes off the seminar with a discussion of case reports from HBOT used in patients with war-related traumatic sequelae, and a time of Q&A for all 3 presenters.
Shai Efrati
Dr. Shai Efrati is a professor at the School of Medicine and the Sagol School of Neuroscience at Tel Aviv University. He also serves as the director of the Sagol Center for Hyperbaric Medicine and Research at Shamir (Assaf-Harofeh) Medical Center in Israel. Under professor Efrati’s leadership, the center has grown to become the largest hyperbaric center worldwide, currently treating over 300 patients per day.
Dr. Efrati’s expertise extends to internal medicine, nephrology, hyperbaric and diving medicine and he holds the position of director of research & development at the Shamir Medical Center, affiliated with Tel-Aviv University. Driven by the passion for physiology and thermodynamics, particularly in understanding the physiological barriers that hinder organ function, he initiated a research program focusing on neuroplasticity – the regeneration of damaged brain tissue. The research aims to treat the brain as a tissue, identifying and characterizing non-healing brain wounds and the bottlenecks that impede recovery.
Among the various potential interventions studied for inducing neuroplasticity, the most promising approach involves the use of dedicated Hyperbaric Oxygen Therapy (HBOT) protocols. This newly developed HBOT protocol stimulates brain and tissue repair by generating fluctuations in oxygen and pressure, initiating a regenerative biological cascade akin to hypoxia under hyperoxic conditions – a phenomenon known as the Hyperoxic-Hypoxic Paradox (HHP). Clinical studies and ongoing research have demonstrated that HHP can induce neuroplasticity in various types of brain injuries, including stroke, traumatic brain injury, post-COVID syndrome, age-related cognitive decline, central pain syndromes such as Fibromyalgia syndrome, and in patients suffering from long-term treatment-resistant PTSD.
Speaker Disclosures:
Financial: Dr. Shai Efrati has employment relationships with AVIV scientific, Sackler School of Medicine, Sagol School of Neuroscience, and the Tel-Aviv University. He receives a speaking honorarium from 小蝌蚪视频. He has no relevant financial relationships with ineligible organizations.
Non-financial: Dr. Shai Efrati has no relevant non-financial relationships.
Keren Doenyas-Barak, MD
Dr. Keren Doenyas-Barak obtained her MD from the Hebrew University in Jerusalem in 2002 and currently teaches physiology and clinical practice at Tel Aviv University’s School of Medicine.
For the past six years, she has led the PTSD unit at Sagol Center for Hyperbaric Medicine and Research, focusing on the biology and pathophysiology of PTSD. Her comprehensive research program covers various aspects of PTSD, including the effects of hyperbaric oxygen therapy, biomarker characterization, and PTSD diagnosis.
Speaker Disclosures:
Financial: Dr. Keren Doenyas-Barak has employment relationships with Tel Aviv University and Assaf-Harofeh Medical Center. She receives grants from Offical Naval research Global. Dr. Barak receives a speaking honorarium from 小蝌蚪视频. She has no relevant financial relationships with ineligible organizations.
Non-financial: Dr. Keren Doenvas-Barak has no relevant non-financial relationships.
Ilan Kutz, MD
Ilan Kutz, MD, is a former assistant professor of psychiatry on the staff of Tel-Aviv University and former head of the psychiatric services at Meir General Hospital, and clinical director of its acute stress and trauma intervention unit. For the past decade, he has served as a consultant for the PTSD unit at the Segol Hyperbaric-Oxygen Research Center at the Shamir Medical Center. He continues working as a psychiatrist and psychotherapist in his private practice.
For several decades, Dr. Kutz had developed methods for treating mass casualty events following terrorist attacks, educating mental health professionals around Israel and abroad. He devised a method for immediate assessment of Acute Stress Reaction (ASR) and risk prediction of subsequent stress disorders and helped develop a phase-oriented intervention-model for treating Acute Stress Disorder (ASD) in victims of terrorist attacks. As a consulting psychiatrist, he assisted the staff of the mental health clinic in the rocket-bombarded town of Sderot.
Speaker Disclosures:
Financial: Dr. Ilan Kutz has an employment relationship with Shamir Medical Center. He receives a speaking honorarium from 小蝌蚪视频. He has no relevant financial relationships with ineligible organizations.
Non-financial: Dr. Ilan Kutz has no relevant non-financial relationships.